ACeDB Metabolism Server
Summary
This server contains information on the synthesis and
degradation of many compound families. After you get connected to the
server, you will find a list of compound families. You need only choose
on your family of interest to find the pathway(s) of degradation or
synthesis.
Example Search of the ACeDB Metabolism Server
We suggest that, if possible, you open another window in your web browser
so that you can follow along with the instructions while you are doing
the search.
- Point your browser to the
ACeDB metabolism server.
- Let's assume that you want to learn about Isoleucine synthesis.
Click on
Isoleucine Synthesis. You will now see an image map of the various
steps involved in isoleucine synthesis. The compounds in blue are
the enzymes involved in a particular reaction and constitute the
so-called "Pathway Class"; those that are in red are the reagents and
products of the reactions and constitute the "Metabolite Class."
- Select Aspartate
Kinase. This will result in the display of an Aspartate
Kinase data sheet. The data sheet will contain a host of data including,
but not limited to:
- The various pathways that said enzyme is involved in
- Major reactants and products involved with the enzymes reactions
- Optimum pH
- Inhibitors
- On the Aspartate Kinase data sheet, select
Isoleucine Synthesis to take you back to the isoleucine image map.
(You could just click on the "back" key or your browser).
- Select
O-Phosphohomoserine. This will result in the display of an
O-Phosphohomoserine data sheet. This data sheet will differ greatly from
the Aspartate Kinase data sheet. Remember that entries in red are of the
"Metabolite Class." As such, the only data that their data sheets
contain are:
- the reactions the compound is consumed in
- the reactions the compound is produced by
- reactions that the compound inhibits
Unfortunately, you don't have the option of viewing any of the
enzymes/proteins involved in the pathway. However, you may point your
web browser to the
PIR
database
and search for your protein there. If you are unfamiliar with PIR, you may
view this
introduction to
PIR.
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Last updated: July 25, 1998
URL: http://biotech.icmb.utexas.edu/pages/science/acedb.html
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