Biochemistry on the Web: Practical Applications

The World Wide Web is home to a host of various biochemical resources. The following practicals will help you gain valuable experience in using these resources.

Question 1: as you learned in earlier units, there are a limited number of protein architectures. It has been hypothesized that enzymes that have similar architectures may be evolutionarily related to one another. In this section we are going to discover which glycolytic enzymes have simiar architectures. One of the resources we will use for this is SCOP, the Structural Classification of Proteins.

Question 2: in this exercise, you will learn about the role of glycolysis in human pathology. You will utilize two resources, the Enzyme Catalogue (EC) and On-line Mendelian Inheritance in Man (OMIM) . These two resources are conveniently connected.

Question 3: you'll use the net to learn about the regulation of metabolic processes. You'll be using a database called PUMA, which stands for Phylogeny, Metabolism, Alignments. This is a database of pathways and regulatory circuits that exist in a variety of different cell types.

Glycolysis Map

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Last updated: July 18, 1998
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